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Jan 22 Brent Burns Sharks Jersey , 2014 : Bharat Book Bureau presents the new report, on 'Frontier Pharma: Rheumatoid Arthritis - Identifying and Commercializing First-in-Class Innovation' the current developmental pipeline is highly innovative beyond these me-too products and incremental innovations and promises a number of first-in-class products across all stages. These new developments are driven by improvements in the understanding of signaling pathways and underlying disease mechanisms of Rheumatoid Arthritis (RA). These highly innovative products are expected to increase the diversity of available products, in terms of mechanism of action over the coming decade and are likely to have a significant impact on the dynamics of the clinical and commercial landscape.

The market is also characterized by high activity in licensing and co-development deals. In particular, there is sustained commercial interest in pipeline biologic therapies with a range of molecular targets. There is also considerable interest in small molecule inhibitors of intracellular kinases despite their clinical performances not being as well established as biologics or mAbs.


- The report analyzes the RA pipeline and strategic alliance landscape with particular emphasis on first-in-class programs.
- A brief introduction to RA, including symptoms Tommy Wingels Jersey , pathophysiology, and an overview of the pharmacotherapy
- Highlights of the changing molecular target landscape between marketed and pipeline products with particular focus on innovation
- A comprehensive review of first-in-class pipeline therapies; the pipeline is analyzed by Phase distribution, molecule type, molecular target, and administration route
- Identification and assessment of first-in-class molecular targets highlighting early-stage programs with clinical utility that has yet to be evaluated Tomas Hertl Jersey , as well as an in-depth literature review of novel molecular targets
- Assessment of the licensing and co-development deals for RA therapeutics

Reasons to buy

The report will assist business development strategies of companies who wish to develop RA therapies with improved benefits to existing treatments. In addition, this report will be of interest to companies seeking to expand pipeline portfolios through licensing agreements and co-development deals allowing them to -
- Understand the overall focal shifts in therapeutic molecular targets of RA treatments
- Identify first-in-class product development and understand the therapeutic and commercial prospects of first-in-class developmental programs based on available animal model data
- Assess the value of products benchmarked against licensed and co-developed therapeutic programs
- Spot first-in-class programs that are potentially available for licensing and co-development deals
Table of contents :
1 Table of Contents 5
1.1 List of Tables 7
1.2 List of Figures 8
2 Introduction 9
2.1 The Case for Innovation 9
2.2 Growing Opportunities for Biologic Products 9
2.3 Diversification of Molecular Targets 9
2.4 Innovative First-in-class Product Developments Remain Attractive 10
2.5 Changes in the Clinical and Commercial Environment to be More Favorable to Products Targeting Niche Patient Populations and Niche Indications 10
2.6 Sustained Innovation 11
3 Rheumatoid Arthritis12
3.1 Disease Overview.12
3.1.1 Disease Symptoms 13
3.1.2 Environmental Factors and Genetic Predisposition 13
3.1.3 Disease Pathophysiology 13
3.1.4 Pharmacotherapy Algorithm 14
3.2 Overview of Marketed Products for Rheumatoid Arthritis 15
3.3 Molecular Type Analysis 16
3.4 Molecular Target Analysis 17
3.4.1 Intracellular Therapeutic Targets 17
3.4.2 Membrane Therapeutic Targets18
3.4.3 Extracellular Targets 18
3.5 Innovative Products in the RA Market 18
3.6 Efficacy and Safety of Marketed Products 21
3.7 Current Unmet Needs 23
4 Overview of Pipeline Products for Rheumatoid Arthritis 24
4.1 Rheumatoid Arthritis Pipeline by Molecule Type, Phase and Therapeutic Targets 24
4.2 Frequently Targeted Intracellular Kinases 26
4.2.1 p38 Kinase 26
4.2.2 MAPK 26
4.2.3 JAK 26
4.2.4 Spleen Tyrosine Kinase (Syk) 26
4.3 Frequently Targeted Cytokines and Receptors 27
4.3.1 TNF-a 27
4.3.2 Toll-Like Receptors 27
4.3.3 B Lymphocyte Stimulator 27
4.4 Efficacy and Safety of Pipeline Products28
4.5 Comparative Distribution of Programs between the RA Market and Pipeline by Therapeutic Target Family 30
4.6 First-in-class Pipeline Programs Targeting Novel Molecule Targets 32
5 Target and Pipeline Program Evaluation 38
5.1 Cytokines and Receptors 38
5.1.1 Pipeline Programs which Target HMGB-1 38
5.1.2 Pipeline Programs which Target IL-10 Receptor 43
5.1.3 Pipeline Programs which Target HSP 60 47
5.1.4 Pipeline Programs which Target Interleukins 15 and 16 50
5.1.5 Pipeline programs which Target Macrophage Migration Inhibitory Factor (MIF) 53
5.2 Integrins 56

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